Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3913842 | 0.86 | KDM4E (0.51) | KDM4EGAAGLAALDH1A1HPGD | |
| SCHEMBL5154097 | 0.86 | KDM4E (0.54) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4430805 | 0.84 | KDM4E (0.47) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4426842 | 0.84 | KDM4E (0.49) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4432534 | 0.84 | KDM4E (0.49) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4430485 | 0.82 | KDM4E (0.41) | KDM4EGAAPDE3BPDE3AALDH1A1 | |
| SCHEMBL4428291 | 0.80 | KDM4E (0.48) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4438837 | 0.80 | ALDH1A1 (0.49) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4431808 | 0.80 | KDM4E (0.50) | KDM4EGAAGLAPDE3BPDE3A | |
| SCHEMBL4426834 | 0.78 | ALDH1A1 (0.54) | KDM4EGAAGLAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |