Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5154097 | 0.93 | KDM4E (0.54) | ALDH1A1KDM4EGAAGLARNASEH1 | |
| SCHEMBL4438532 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EGAAGLARNASEH1 | |
| SCHEMBL4428809 | 0.86 | DAO (0.48) | ALDH1A1KDM4EGAAGLAMAPT | |
| SCHEMBL4437957 | 0.86 | PDE3B (0.51) | ALDH1A1KDM4EGAAGLAMAPT | |
| SCHEMBL4430805 | 0.86 | KDM4E (0.47) | ALDH1A1KDM4EGAAGLATSHR | |
| SCHEMBL4426834 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KDM4EGAAGLARNASEH1 | |
| SCHEMBL4426842 | 0.86 | KDM4E (0.49) | ALDH1A1KDM4EGAAGLARNASEH1 | |
| SCHEMBL4432424 | 0.85 | HNF4A (0.49) | KDM4ERNASEH1PARP1MPODAO | |
| SCHEMBL4428291 | 0.85 | KDM4E (0.48) | ALDH1A1KDM4EGAAGLARNASEH1 | |
| SCHEMBL4429436 | 0.81 | KDM4E (0.53) | ALDH1A1KDM4EGAAGLARNASEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |