Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.37 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438025 | 0.86 | KDM4E (0.41) | KDM4EAKR1C3KDM4CKDM4AKDM5B | |
| SCHEMBL4428237 | 0.86 | KDM4E (0.50) | KDM4EKDM4CKDM4AKDM5BKDM6B | |
| SCHEMBL11836193 | 0.86 | KDM4E (0.42) | KDM4EKDM4CKDM4AKDM5BKDM6B | |
| SCHEMBL3912930 | 0.85 | KDM4E (0.53) | KDM4EKDM4CKDM4AKDM5BKDM6B | |
| SCHEMBL3917621 | 0.84 | DAO (0.46) | KDM4EKDM4CKDM4AKDM5BKDM6B | |
| SCHEMBL3920671 | 0.84 | DAO (0.54) | KDM4EKDM4CKDM4AKDM5BDAO | |
| SCHEMBL4433258 | 0.83 | KDM4E (0.55) | KDM4EKDM4CKDM4AKDM5BKDM6B | |
| SCHEMBL4433934 | 0.82 | KDM4E (0.51) | KDM4EPDE3BPDE3AALDH1A1GAA | |
| SCHEMBL4431491 | 0.82 | HCAR2 (0.54) | KDM4EKDM4CKDM4AKDM5BKDM6B | |
| SCHEMBL11835232 | 0.81 | KDM4E (0.59) | KDM4EKDM5BDAOALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |