Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 3/20 | 0.37 |
| ▸ | GOT1 | P17174 | 1/20 | 0.37 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.37 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434132 | 1.00 | GAA (0.51) | GAASMN1; SMN2HSD17B3HSD17B10NOTUM | |
| SCHEMBL3917385 | 0.79 | BRPF1 (0.54) | GAAHSD17B3BRPF1AADATGOT1 | |
| SCHEMBL3917387 | 0.79 | BRPF1 (0.54) | GAAHSD17B3BRPF1AADATGOT1 | |
| Hydrochloric Acid SCHEMBL21751195 | 0.78 | BRPF1 (0.53) | GAABRPF1AADATGOT1KYAT1 | |
| Hydrochloric Acid SCHEMBL2235587 | 0.78 | BRPF1 (0.53) | GAABRPF1AADATGOT1KYAT1 | |
| Hydrochloric Acid SCHEMBL21751196 | 0.78 | BRPF1 (0.53) | GAABRPF1AADATGOT1KYAT1 | |
| Hydrochloric Acid SCHEMBL2235585 | 0.78 | BRPF1 (0.53) | GAABRPF1AADATGOT1KYAT1 | |
| SCHEMBL8893469 | 0.75 | CA12 (0.40) | MEN1KMT2AXIAP | |
| SCHEMBL645717 | 0.74 | LMNA (0.43) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL645716 | 0.73 | LMNA (0.42) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711470-B1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVTIY OF GAMMA-SECRETASE | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | disclosed |
| US-7160875-B2 | Malonamide derivatives | HOFFMANN-LA RACHE INC. (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1711470-A1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVTIY OF GAMMA-SECRETASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005023772-A1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVITY OF GAMA-SECRETASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | disclosed |
| US-20050054633-A1 | secretase inhibitors; therapy for Alzheimer's disease | HOFFMANN-LA ROCHE INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054633-A1 | secretase inhibitors; therapy for Alzheimer's disease | BACE1, BACE2, APP | GAA 21/4885SMN1; SMN2 1961/4885HSD17B3 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.