Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL10412876 | 0.98 | LMNA (0.50) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| Acetone SCHEMBL4283217 | 0.93 | GAA (0.54) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| Bicarbonate SCHEMBL6755891 | 0.93 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| Hydrogen Peroxide SCHEMBL29268503 | 0.93 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| Oxalic Acid SCHEMBL7319784 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| Acetone SCHEMBL2978474 | 0.91 | GAA (0.52) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| Benzene SCHEMBL5085625 | 0.91 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| SCHEMBL34 | 0.91 | GAA (0.62) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| SCHEMBL31313 | 0.91 | GAA (0.62) | SMN1; SMN2TSHRGAAALDH1A1LMNA | |
| SCHEMBL1705904 | 0.91 | GAA (0.62) | SMN1; SMN2TSHRGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 760 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116115581-A | Ketorolac tromethamine biphasic controlled release tablet and preparation method thereof | 中国人民解放军中部战区总医院 | 2023-05-16 | — | — | CN | claimed |
| EP-2305624-B1 | Self-degradable explosive device | MAXAMCORP HOLDING SL (ES) | 2017-09-27 | — | — | EP | claimed |
| CN-103284974-B | Benzene ring nonyl ester double-layer osmotic pump controlled-release tablet and preparation method thereof | WUHAN GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND, PLA (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-103860514-A | Oxybutynin hydrochloride osmotic pump controlled release tablets and preparation method thereof | HEFEI HUAFANG PHARMACEUTICAL SCIENCES & TECHNOLOGY CO LTD | 2014-06-18 | — | — | CN | claimed |
| US-8585841-B2 | Systems and methods for chemical and/or mechanical remediation of nitro compounds and nitrate esters | MAXAMCORP HOLDING S.L. (ES) | 2013-11-19 | — | — | US | claimed |
| WO-2013168177-A2 | OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEMS | RUBICON RESEARCH PRIVATE LIMITED (IN) | 2013-11-14 | — | — | WO | claimed |
| CN-103284974-A | Phencynonate hydrochloride double-layer osmotic pump controlled release tablet and preparation method thereof | WUHAN GENERAL HOSPITAL OF GUANGZHOU MILITARY | 2013-09-11 | — | — | CN | claimed |
| US-8529955-B2 | Methods of treatment using a gastric retained gabapentin dosage | DEPOMED, INC. (US) | 2013-09-10 | — | — | US | claimed |
| US-8440232-B2 | Methods of treatment using a gastric retained gabapentin dosage | DEPOMED, INC. (US) | 2013-05-14 | — | — | US | claimed |
| CN-102552205-A | Potassium citrate controlled-release tablet preparation and preparation method thereof | SHANGHAI INST MATERIA MEDICA | 2012-07-11 | — | — | CN | claimed |
| WO-2004050066-A1 | MICROSPHERES AND RELATED PROCESSES AND PHARMACEUTICAL COMPOSITIONS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2004-06-17 | — | — | WO | claimed |
| US-6706283-B1 | INCREASING BIOAVAILABILITY OF SPARINGLY WATER SOLUBLE ACTIVE INGREDIENTS; CONTROLLED INFLUX OF WATER TO CORE USING NON-DISSOLVING, NONERODING COATING | PFIZER INC | 2004-03-16 | — | — | US | claimed |
| WO-2004010982-A1 | METHOD OF PREPARING SOLID DOSAGE FORMS COATED IN TWO LAYERS COMPRISING A WATER-INSOLUBLE POLYMER AND A WATER-SOLUBLE PORE FORMER | PHARMACIA CORPORATION (US) | 2004-02-05 | — | — | WO | claimed |
| WO-2003092660-A1 | MONOCOMPARTMENT OSMOTIC CONTROLLED DRUG DELIVERY SYSTEM | RANBAXY LABORATORIES LIMITED (US) | 2003-11-13 | — | — | WO | claimed |
| US-6365185-B1 | ORAL TABLET FOR DELIVERING BENEFICIAL AGENT TO MAMMAL COMPRISING CORE COMPARTMENT HAVING BENEFICIAL AGENT SURROUNDED BY UNITARY SELF-DESTRUCTING SHELL COMPRISING PLURALITY OF DISINTEGRANT PARTICLES DISPERSED WITHIN SEMIPERMEABLE MATRIX | UNIVERSITY OF CINCINNATI | 2002-04-02 | — | — | US | claimed |
| EP-1027888-A2 | Osmotic system for delivery of solid amorphous dispersions of drugs | Pfizer Products Inc. (US) | 2000-08-16 | — | — | EP | claimed |
| US-5612059-A | CELLULOSE DERIVATIVE, DRUG DELIVERY | PFIZER INC. (US) | 1997-03-18 | — | — | US | claimed |
| US-5458887-A | OF AN OSMOTIC CORE CONTAINING A DRUG AND A WATER SWELLABLE COMPONENT AND A WATER RESISTANT POLYMER COATING CONTAINING A COMPOUND WHICH DISSOLVES IN GASTROINTESTINAL FLUID | ANDRX PHARMACEUTICALS, INC. (US) | 1995-10-17 | — | — | US | claimed |
| EP-0326727-A1 | Sustained release implant and method for preparing same | INTERNATIONAL MINERALS AND CHEMICAL CORPORATION (US) | 1989-08-09 | — | — | EP | claimed |
| US-4761289-A | Sustained release implant and method for preparing same | INTERNATIONAL MINERALS & CHEMICAL CORP. (US) | 1988-08-02 | — | — | US | claimed |