Oxalic Acid

Oxalic Acid

SCHEMBL7319784

Cc1ccc(S(=O)(=O)O)cc1.O=C(O)C(=O)O

nearest known ligand 0.52

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Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.52
TSHR P16473 2/20 0.52
GAA P10253 2/20 0.52
LMNA P02545 3/20 0.51
ALDH1A1 P00352 3/20 0.51
KDM4E B2RXH2 1/20 0.51
MAPT P10636 1/20 0.51
HTT P42858 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
CYP2D6 P10635 3/20 0.50
MAPK1 P28482 1/20 0.50
SNCA P37840 1/20 0.49
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
MMP1 P03956 1/20 0.48
MMP2 P08253 1/20 0.48
MMP9 P14780 1/20 0.48
MMP8 P22894 1/20 0.48
MMP13 P45452 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL6755891 0.93 SMN1; SMN2 (0.54) SMN1; SMN2TSHRGAALMNAALDH1A1
Hydrogen Peroxide SCHEMBL29268503 0.93 SMN1; SMN2 (0.59) SMN1; SMN2TSHRGAALMNAALDH1A1
Acetic Acid SCHEMBL443433 0.91 SMN1; SMN2 (0.52) SMN1; SMN2TSHRGAALMNAALDH1A1
Benzene SCHEMBL5085625 0.91 SMN1; SMN2 (0.64) SMN1; SMN2TSHRGAALMNAALDH1A1
SCHEMBL1705904 0.91 GAA (0.62) SMN1; SMN2TSHRGAALMNAALDH1A1
P-Xylene SCHEMBL8660591 0.91 GAA (0.62) SMN1; SMN2TSHRGAALMNAALDH1A1
SCHEMBL5068661 0.91 GAA (0.62) SMN1; SMN2TSHRGAALMNAALDH1A1
SCHEMBL31313 0.91 GAA (0.62) SMN1; SMN2TSHRGAALMNAALDH1A1
SCHEMBL34 0.91 GAA (0.62) SMN1; SMN2TSHRGAALMNAALDH1A1
SCHEMBL11432043 0.91 GAA (0.62) SMN1; SMN2TSHRGAALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0333743-A1 USE OF NICORANDIL TO TREAT ALOPECIA THE UPJOHN COMPANY (US) 1989-09-27 EP claimed
WO-1988004171-A1 USE OF NICORANDIL TO TREAT ALOPECIA THE UPJOHN COMPANY (US) 1988-06-16 WO claimed
EP-0658548-B1 Benzenesulfonamide derivative and process for preparing thereof TANABE SEIYAKU CO (JP) 1997-11-19 EP disclosed
EP-0658548-A1 Benzenesulfonamide derivative and process for preparing thereof TANABE SEIYAKU CO., LTD. (JP) 1995-06-21 EP disclosed