Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | AHCY | P23526 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434892 | 0.89 | MCOLN3 (0.35) | LMNAMAPTHTTALDH1A1KMT2A | |
| SCHEMBL4444516 | 0.88 | MAPK1 (0.40) | MAPK1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4445379 | 0.88 | RPLP1 (0.38) | MAPK1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL4444773 | 0.88 | HTT (0.38) | LMNASMN1; SMN2MAPTHTTKMT2A | |
| SCHEMBL5262268 | 0.88 | MAPT (0.40) | MAPK1LMNASLC6A4SMN1; SMN2MAPT | |
| SCHEMBL4445337 | 0.88 | MAPT (0.40) | MAPK1LMNASLC6A4SMN1; SMN2MAPT | |
| SCHEMBL4436446 | 0.87 | JAK2 (0.37) | LMNAMAPTHTTNOS1NOS2 | |
| SCHEMBL4439944 | 0.86 | KMT2A (0.36) | SLC6A2SLC6A4SLC6A3SMN1; SMN2HTT | |
| SCHEMBL4436874 | 0.86 | HTT (0.37) | LMNASMN1; SMN2MAPTHTTKMT2A | |
| SCHEMBL4439398 | 0.84 | KDM4E (0.40) | MAPK1LMNASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |