Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPD | P32754 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445337 | 1.00 | MAPT (0.40) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL4434892 | 0.89 | MCOLN3 (0.35) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL4437504 | 0.88 | MAPT (0.45) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL4434895 | 0.88 | MAPK1 (0.37) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL4444773 | 0.87 | HTT (0.38) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4445379 | 0.87 | RPLP1 (0.38) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL4436446 | 0.86 | JAK2 (0.37) | MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL4439944 | 0.85 | KMT2A (0.36) | KMT2AALDH1A1CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL4436874 | 0.85 | HTT (0.37) | MAPTMEN1KMT2ACYP2D6LMNA | |
| SCHEMBL4439398 | 0.84 | KDM4E (0.40) | MAPTMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802586-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044823-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2006-04-27 | — | — | WO | disclosed |