Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436874 | 0.91 | HTT (0.37) | HTTNPC1LMNARAB9AHCAR3 | |
| SCHEMBL4439398 | 0.89 | KDM4E (0.40) | HTTNPC1LMNARAB9AHCAR3 | |
| SCHEMBL4434892 | 0.89 | MCOLN3 (0.35) | HTTNPC1LMNARAB9AMAPT | |
| SCHEMBL4437157 | 0.88 | HCAR3 (0.39) | HTTNPC1LMNARAB9AHCAR3 | |
| SCHEMBL4434895 | 0.88 | MAPK1 (0.37) | HTTNPC1LMNARAB9AMAPT | |
| SCHEMBL4445379 | 0.87 | RPLP1 (0.38) | HTTNPC1LMNARAB9AMAPT | |
| SCHEMBL5262268 | 0.87 | MAPT (0.40) | LMNAMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4445337 | 0.87 | MAPT (0.40) | LMNAMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4436446 | 0.86 | JAK2 (0.37) | HTTNPC1LMNARAB9AMAPT | |
| SCHEMBL4439944 | 0.85 | KMT2A (0.36) | HTTKMT2ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |