Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RPLP1 | P05386 | 2/20 | 0.32 |
| ▸ | RPLP0 | P05388 | 2/20 | 0.32 |
| ▸ | RPS17 | P08708 | 2/20 | 0.32 |
| ▸ | RPSA | P08865 | 2/20 | 0.32 |
| ▸ | RPS2 | P15880 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438072 | 0.92 | MEN1 (0.35) | KDM4EGAAALDH1A1LMNANPC1 | |
| SCHEMBL4434895 | 0.89 | MAPK1 (0.37) | ALDH1A1LMNANPC1HTTRAB9A | |
| SCHEMBL4444773 | 0.89 | HTT (0.38) | GAALMNANPC1HTTRAB9A | |
| SCHEMBL4445379 | 0.89 | RPLP1 (0.38) | MCOLN3KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL5262268 | 0.89 | MAPT (0.40) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL4445337 | 0.89 | MAPT (0.40) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL4433895 | 0.88 | KDM4E (0.39) | MCOLN3KDM4EGAAALDH1A1LMNA | |
| SCHEMBL4436446 | 0.88 | JAK2 (0.37) | GAAALDH1A1LMNANPC1HTT | |
| SCHEMBL4439944 | 0.87 | KMT2A (0.36) | ALDH1A1HTTNPSR1KMT2ACYP3A4 | |
| SCHEMBL4436874 | 0.87 | HTT (0.37) | GAALMNANPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |