Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2962867 | 0.85 | SMYD3 (0.49) | SMN1; SMN2L3MBTL1ACKR3SMYD3MEN1 | |
| SCHEMBL11878066 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1ACKR3SMYD3MEN1 | |
| SCHEMBL27917306 | 0.82 | OPRD1 (0.37) | SMN1; SMN2ACKR3HTR2BHTT | |
| SCHEMBL3682800 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1ACKR3MEN1KMT2A | |
| SCHEMBL27916927 | 0.81 | HTR2B (0.37) | SMN1; SMN2ACKR3HTR2BHTT | |
| SCHEMBL27917391 | 0.80 | OPRD1 (0.35) | SMN1; SMN2L3MBTL1ACKR3SMYD3HTR2B | |
| SCHEMBL27935665 | 0.80 | BTK (0.42) | SMN1; SMN2L3MBTL1ACKR3 | |
| SCHEMBL27935713 | 0.80 | JAK3 (0.36) | ACKR3HTR2B | |
| SCHEMBL9651228 | 0.79 | SIGMAR1 (0.61) | L3MBTL1ACKR3POLBJAK2 | |
| SCHEMBL19710364 | 0.78 | SMYD3 (0.61) | SMN1; SMN2L3MBTL1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101959882-B | Imidazole carbonyl compound | DAIICHI SANKYO CO LTD | 2013-09-11 | — | — | CN | disclosed |
| EP-2013211-A2 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | Novartis AG (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007121920-A2 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |