SCHEMBL4435101

SCHEMBL4435101

CCOC(=O)CCCOc1ccc(Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.54
CYSLTR2 Q9NS75 1/20 0.54
CYSLTR1 Q9Y271 1/20 0.54
MAPT P10636 2/20 0.53
ABCB11 O95342 1/20 0.53
LMNA P02545 1/20 0.53
MAPK1 P28482 1/20 0.53
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C19 P33261 1/20 0.52
LTA4H P09960 2/20 0.52
HRH2 P25021 1/20 0.52
HRH1 P35367 1/20 0.52
CNR1 P21554 1/20 0.52
HPGD P15428 2/20 0.51
KMT2A Q03164 2/20 0.51
BLM P54132 1/20 0.51
PMP22 Q01453 1/20 0.51
RAB9A P51151 1/20 0.51
MEN1 O00255 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21991489 0.92 CYP1A2 (0.54) MAPTABCB11LMNAMAPK1CYP1A2
SCHEMBL19705161 0.90 CYP1A2 (0.52) MAPTABCB11LMNACYP1A2CYP3A4
SCHEMBL11566246 0.90 MAPT (0.54) BRD4CYSLTR2CYSLTR1MAPTABCB11
SCHEMBL15363151 0.89 PDK2 (0.49) BRD4CYSLTR2CYSLTR1MAPTABCB11
Ethane SCHEMBL16527398 0.88 BRD4 (0.48) BRD4CYSLTR2CYSLTR1MAPTABCB11
SCHEMBL21991515 0.88 TDP1 (0.50) MAPTABCB11LMNAMAPK1CYP1A2
SCHEMBL6937314 0.87 MEN1 (0.62) BRD4CYSLTR2CYSLTR1MAPTLTA4H
SCHEMBL15363152 0.86 BRD4 (0.46) BRD4CYSLTR2CYSLTR1MAPTABCB11
SCHEMBL11566476 0.86 CYP4F2 (0.56) MAPTABCB11LMNAMAPK1LTA4H
SCHEMBL19692569 0.86 LTA4H (0.70) LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-05-23 US disclosed
CN-112657542-B Method for preparing p-aminophenol from nitrobenzene 常州大学 2023-09-22 CN disclosed
US-20230165848-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-06-01 US disclosed
US-20230165848-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-06-01 US disclosed
US-20230165848-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-06-01 US disclosed
US-11547704-B2 Chemical compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-01-10 US disclosed
US-11547704-B2 Chemical compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-01-10 US disclosed
EP-3468960-B1 CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2022-03-23 EP disclosed
CN-109563071-B Chemical compounds as inhibitors of the ATF4pathway 葛兰素史密斯克莱知识产权发展有限公司 2021-08-03 CN disclosed
EP-1877067-A1 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA Microbia, Inc. (US) 2008-01-16 EP disclosed
WO-2006124713-A2 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES MICROBIA, INC. (US) 2006-11-23 WO disclosed
WO-2006122186-A2 1,4-DIPHENYL-3-HYDROXYALKYL-2-AZETIDINONE DERIVATIVES FOR TREATING HYPERCHOLESTROLEMIA MICROBIA, INC. (US) 2006-11-16 WO disclosed
WO-2006121861-A2 BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS MICROBIA, INC. (US) 2006-11-16 WO disclosed
WO-2006116499-A1 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA MICROBIA, INC. (US) 2006-11-02 WO disclosed
US-RE37770-E1 SUCH AS LINOLEIC ACID, OLEIC ACID, 5,8,11,14-EICOSATETRAYNOIC ACID, 4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYL)THIOACETIC ACID, CLOFIBRATE, AND GEMFIBROZIL; USEFUL FOR TREATING DISORDERS OF EPIDERMAL DIFFERENTIATION AND PROLIFERATION. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-06-25 US disclosed
US-6187814-B1 BY TOPICALLY AN FARNESOID X-ACTIVATED RECEPTOR (FXR) ACTIVATOR SELECTED FROM FARNESAL, ALKYL FARNESYL ETHER, ALKYL FARNESOATE, AND 7-METHYL-9-(3,3-DIMETHYLOXIRANYL)-3-METHYL-2,6-NONADIENOIC ACID, ALKYL ESTER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-02-13 US disclosed
US-6184215-B1 TOPICALLY APPLYING TO SKIN A HYDROXYCHOLESTEROL TO ACTIVATE LIVER-BASED X-ACTIVATED RECEPTOR ALPHA (LXRA) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-02-06 US disclosed
US-6060515-A TOPICALLY APPLYING TO MAMMALIAN SKIN OR MUCOUS MEMBRANE A BARRIER DEVELOPMENT ENHANCING AMOUNT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARA) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-05-09 US disclosed
CN-1248916-A Use of FXR, PPAR 'alpha' and LXR 'alpha' activators to restore barrier function, promote epidermal differentiation and inhibit proliferation UNIV CALIFORNIA (US) 2000-03-29 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 BRD4 1133/4885CYSLTR2 2729/4885CYSLTR1 2836/4885
US-20230165848-A1 CHEMICAL COMPOUNDS ATF4, XBP1, EIF2B5 BRD4 203/4885CYSLTR2 1557/4885CYSLTR1 1121/4885
US-11547704-B2 Chemical compounds ATF4, XBP1, EIF2B5 BRD4 186/4885CYSLTR2 1602/4885CYSLTR1 1142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.