Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570645 | 0.76 | HDAC4 (0.43) | HDAC4SLC6A4OPRK1OPRM1PDE7A | |
| SCHEMBL4437244 | 0.76 | HDAC4 (0.43) | HDAC4MEN1KMT2ATDP1HDAC3 | |
| SCHEMBL7564524 | 0.75 | PSEN1 (0.43) | HDAC4SLC6A4OPRK1OPRM1PDE7A | |
| SCHEMBL4435176 | 0.75 | MEN1 (0.36) | HDAC4SLC6A4OPRK1OPRM1MEN1 | |
| SCHEMBL23352310 | 0.75 | SLC6A4 (0.40) | HDAC4GRIN1GRIN2ASLC6A4GRIN2D | |
| SCHEMBL7571494 | 0.73 | P2RX7 (0.35) | HDAC4OPRK1OPRM1P2RX7 | |
| SCHEMBL6260698 | 0.73 | SIGMAR1 (0.40) | LMNAOPRK1OPRM1ALDH1A1KMT2A | |
| SCHEMBL5642948 | 0.71 | HDAC4 (0.43) | HDAC4GRIN1GRIN2ASLC6A4GRIN2D | |
| SCHEMBL4445342 | 0.69 | SLC6A4 (0.46) | HDAC4SLC6A4LMNAOPRK1ALDH1A1 | |
| SCHEMBL3389630 | 0.68 | HDAC4 (0.49) | HDAC4GRIN1GRIN2ASLC6A4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |