Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31424248 | 0.85 | FFAR1 (0.39) | FFAR1KMT2AF10FFAR4 | |
| SCHEMBL4425976 | 0.80 | TAAR1 (0.52) | FFAR1MAOAMAOBKMT2A | |
| SCHEMBL8270585 | 0.80 | ALDH1A1 (0.52) | RIPK1FFAR1MAOAMAOBDAO | |
| SCHEMBL3578367 | 0.80 | IAPP (0.49) | RIPK1FFAR1MAOAMAOBDAO | |
| SCHEMBL586063 | 0.78 | FFAR1 (0.58) | FFAR1FFAR4 | |
| SCHEMBL4435822 | 0.78 | TAAR1 (0.57) | RIPK1FFAR1KMT2AF10 | |
| SCHEMBL19193176 | 0.77 | FFAR1 (0.42) | FFAR1KMT2AF10FFAR4ALDH1A1 | |
| SCHEMBL6913578 | 0.77 | CYP4F2 (0.61) | RIPK1MAOAMAOBALDH1A1 | |
| SCHEMBL11132861 | 0.77 | RAB9A (0.51) | FFAR1KMT2AHDAC1HDAC6ALDH1A1 | |
| SCHEMBL1874608 | 0.77 | DAO (0.42) | RIPK1FFAR1MAOAMAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805156-A4 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORP (US) | 2009-06-10 | — | — | EP | claimed |
| EP-1805156-A2 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044775-A2 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | claimed |