Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15009887 | 0.82 | ALDH1A1 (0.77) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL26970150 | 0.81 | ALDH1A1 (0.70) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL28254937 | 0.80 | ALDH1A1 (0.74) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL13632352 | 0.80 | POLB (0.65) | ALDH1A1GAAL3MBTL1PKMLMNA | |
| SCHEMBL19392199 | 0.79 | L3MBTL1 (0.54) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL5308780 | 0.79 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1PKMLMNAHTT | |
| SCHEMBL4442881 | 0.79 | PKM (0.69) | ALDH1A1GAAMEN1KMT2APKM | |
| SCHEMBL12793309 | 0.78 | POLB (0.67) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL24295449 | 0.78 | EPHX2 (0.75) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL309130 | 0.78 | MAPT (0.63) | ALDH1A1GAAL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118089-A1 | INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008095821-A1 | INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-14 | — | — | WO | disclosed |