Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166325 | 0.80 | KDM4E (0.52) | SMN1; SMN2MAPK1RAB9ADCPSALDH1A1 | |
| SCHEMBL2166078 | 0.80 | ALDH1A1 (0.58) | SMN1; SMN2USP2ALDH1A1KMT2ANPSR1 | |
| SCHEMBL2168221 | 0.78 | HPGD (0.51) | SMN1; SMN2MAPK1DCPSALDH1A1MEN1 | |
| SCHEMBL2166122 | 0.78 | MEN1 (0.52) | SMN1; SMN2DHFRALDH1A1MEN1KMT2A | |
| SCHEMBL2166066 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2MAPK1RAB9ADCPSUSP2 | |
| SCHEMBL2164157 | 0.78 | L3MBTL1 (0.50) | SMN1; SMN2MAPK1DCPSALDH1A1GAA | |
| SCHEMBL2166586 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPK1USP2ALDH1A1MEN1 | |
| SCHEMBL2166042 | 0.77 | RAB9A (0.53) | SMN1; SMN2MAPK1RAB9ADCPSDHFR | |
| SCHEMBL2166596 | 0.77 | USP2 (0.60) | SMN1; SMN2MAPK1RAB9AUSP2ALDH1A1 | |
| SCHEMBL2165366 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1USP2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069316-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Families of Spinal Muscular Atrophy (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008016973-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | FAMILIES OF SPINAL MUSCULAR ATROPHY (US) | 2008-02-07 | — | — | WO | disclosed |