Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD2 | O14939 | 19/20 | 0.64 |
| ▸ | PLD1 | Q13393 | 18/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.60 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.60 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996577 | 0.91 | PLD2 (0.66) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4436922 | 0.89 | YEATS4 (0.75) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4997266 | 0.88 | PLD2 (0.57) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4437923 | 0.87 | PLD1 (0.63) | PLD2PLD1DRD2YEATS4MLLT3 | |
| Hydrochloric Acid SCHEMBL5032194 | 0.86 | PLD1 (0.62) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4437897 | 0.85 | DRD2 (0.69) | PLD2PLD1DRD2KCNH2 | |
| SCHEMBL4446707 | 0.84 | PLD1 (0.70) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4440131 | 0.83 | PLD1 (0.61) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4438930 | 0.82 | PLD1 (0.72) | PLD2PLD1DRD2YEATS4MLLT3 | |
| SCHEMBL4435841 | 0.82 | PLD1 (0.72) | PLD2PLD1DRD2YEATS4MLLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |