Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 6/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PTGIR | P43119 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447530 | 0.92 | KMO (0.56) | KDM4EHSD17B10TSHRKMOFABP4 | |
| SCHEMBL1398456 | 0.83 | MAPT (0.46) | KDM4EHSD17B10PDE4BPDE4D | |
| SCHEMBL13332354 | 0.80 | SLC9A1 (0.41) | AR | |
| SCHEMBL13644162 | 0.80 | POLB (0.45) | KDM4EHSD17B10TSHRKMOHPGD | |
| SCHEMBL1398508 | 0.78 | MAPT (0.47) | KDM4EHSD17B10KMOPDE4BHPGD | |
| SCHEMBL418623 | 0.76 | STAT3 (0.50) | TSHRFABP4FABP5STAT3PTGDR2 | |
| SCHEMBL22965232 | 0.74 | KMO (0.82) | KDM4EHSD17B10TSHRKMOFABP4 | |
| SCHEMBL12809063 | 0.73 | CYP1A2 (0.33) | AR | |
| SCHEMBL1398518 | 0.72 | MAPT (0.39) | KDM4EHSD17B10HPGDAR | |
| SCHEMBL22965217 | 0.70 | KMO (0.51) | KDM4EHSD17B10TSHRKMOFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137181-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008128951-A1 | OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |