Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27702953 | 0.92 | TNF (0.55) | HPGDTNFGAALMNAKMT2A | |
| SCHEMBL18055503 | 0.87 | FNTA (0.59) | CNR2HPGDFNTAFNTBGAA | |
| SCHEMBL4617540 | 0.87 | CYP2C19 (0.55) | LMNANPC1KMT2AMEN1 | |
| SCHEMBL4435743 | 0.84 | TNF (0.50) | TNFGAALMNAL3MBTL1TDP1 | |
| SCHEMBL2356414 | 0.83 | FNTA (0.52) | FNTAFNTBLMNAUTS2R | |
| SCHEMBL4441848 | 0.81 | CACNA1A (0.57) | HPGDTNFGAALMNAKMT2A | |
| SCHEMBL28036009 | 0.80 | L3MBTL1 (0.63) | HPGDGAALMNANPC1RAB9A | |
| SCHEMBL10953096 | 0.80 | LMNA (0.76) | CNR2FNTAFNTBGAALMNA | |
| SCHEMBL1980002 | 0.79 | KMT2A (0.55) | LMNAKMT2AMEN1 | |
| SCHEMBL6289377 | 0.79 | TNF (0.52) | CNR2TNFNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |