Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.61 |
| ▸ | ADH5 | P11766 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.49 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.49 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13002843 | 0.88 | SLC2A1 (0.61) | KMOSLC2A1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL29707122 | 0.83 | ESR2 (0.58) | KMOADH5ALDH1A1GAAKDM4E | |
| SCHEMBL121338 | 0.83 | ESR2 (0.58) | KMOADH5ALDH1A1GAAKDM4E | |
| SCHEMBL28439295 | 0.83 | KMO (0.64) | KMOSLC2A1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL3517388 | 0.83 | KMO (0.64) | KMOSLC2A1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL31209946 | 0.83 | KMO (0.64) | KMOSLC2A1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL4429178 | 0.82 | ADH5 (0.62) | SLC2A1ADH5ALDH1A1GAAIP6K1 | |
| SCHEMBL8637967 | 0.82 | KMO (0.59) | KMOSLC2A1MKNK1MKNK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5753140 | 0.82 | ESR2 (0.56) | KMOADH5ALDH1A1GAAKDM4E | |
| SCHEMBL31658246 | 0.82 | AKR1C3 (0.61) | KMOADH5ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538121-B2 | Vanilloid receptor modulators | GLAXO GROUP LIMITED (GB) | 2009-05-26 | — | — | US | disclosed |
| EP-2033953-A1 | Vanilloid receptor modulators | Glaxo Group Limited (GB) | 2009-03-11 | — | — | EP | disclosed |
| US-20060142333-A1 | Vanilloid receptor modulators | MACDONALD GREGOR J | 2006-06-29 | — | — | US | disclosed |
| EP-1480954-A1 | VANILLOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003068749-A1 | VANILLOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142333-A1 | Vanilloid receptor modulators | TRPV1, NPSR1, TRPV3 | KMO 2936/4885SLC2A1 1762/4885MKNK1 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.