Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 16/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429035 | 0.84 | KCNH2 (0.50) | KCNH2LMNAL3MBTL1 | |
| SCHEMBL4427594 | 0.81 | KCNH2 (0.52) | KCNH2 | |
| Hydrochloric Acid SCHEMBL7156636 | 0.79 | CYP11B1 (0.47) | — | |
| Hydrochloric Acid SCHEMBL4427706 | 0.79 | CYP11B1 (0.47) | — | |
| SCHEMBL4427774 | 0.77 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL4436261 | 0.77 | NCOA3 (0.50) | KCNH2 | |
| SCHEMBL4433926 | 0.77 | MGLL (0.42) | — | |
| SCHEMBL4435540 | 0.75 | KCNH2 (0.53) | KCNH2 | |
| SCHEMBL4423521 | 0.75 | KCNH2 (0.69) | KCNH2 | |
| SCHEMBL4428123 | 0.74 | KCNH2 (0.45) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-B1 | IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | disclosed |
| US-20020151715-A1 | Imidazole derivatives | EVOTEC INTERNATIONAL GMBH (DE) | 2002-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151715-A1 | Imidazole derivatives | GRIN2B, GRIN1, GRIN2A | KCNH2 352/4885LMNA 4581/4885L3MBTL1 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.