Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381679 | 0.81 | MEN1 (0.47) | POLQKDM4ETDP1ATMNPSR1 | |
| SCHEMBL4073210 | 0.78 | CYP3A4 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL1273081 | 0.78 | CYP3A4 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3950927 | 0.74 | MEN1 (0.46) | KDM4ETDP1ATMNPSR1ALDH1A1 | |
| SCHEMBL4374632 | 0.73 | GUCY1B2 (0.36) | PTGS2MEN1KMT2APOLBPPARG | |
| SCHEMBL4659729 | 0.73 | CYP2A6 (0.48) | ALDH1A1POLB | |
| SCHEMBL3958818 | 0.73 | KDM4E (0.47) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3232626 | 0.71 | EPHX2 (0.62) | KDM4ETDP1ATMNPSR1ALDH1A1 | |
| SCHEMBL28332082 | 0.71 | POLQ (0.49) | POLQKDM4ETDP1ATMNPSR1 | |
| SCHEMBL1539491 | 0.70 | VNN1 (0.42) | MEN1KMT2APOLBANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114388-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008098105-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |