Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 5/20 | 0.36 |
| ▸ | GUCY1A2 | P33402 | 5/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539491 | 0.79 | VNN1 (0.42) | ANO1POLBRAB9AMEN1KMT2A | |
| SCHEMBL4374146 | 0.79 | KMT2A (0.41) | NPC1POLBRAB9AMEN1KMT2A | |
| SCHEMBL1273081 | 0.78 | CYP3A4 (0.46) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4073210 | 0.78 | CYP3A4 (0.46) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3722221 | 0.77 | RIPK1 (0.40) | SMN1; SMN2POLB | |
| SCHEMBL3950927 | 0.74 | MEN1 (0.46) | POLBMEN1KMT2A | |
| SCHEMBL3960044 | 0.73 | RIPK1 (0.41) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4436295 | 0.73 | POLQ (0.43) | ANO1POLBPTGS2PPARGMEN1 | |
| SCHEMBL7414670 | 0.73 | POLB (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1SMN1; SMN2 | |
| SCHEMBL4594149 | 0.72 | RAB9A (0.43) | SMN1; SMN2NPC1POLBRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |