SCHEMBL443678

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL444812	0.84	HDAC8 (0.61)	HDAC8CA12CA1CA2CA7
	SCHEMBL443508	0.82	HDAC8 (0.52)	HDAC8
	SCHEMBL443233	0.82	HDAC8 (0.52)	HDAC8ALDH1A1ADRA1AADRA1BDRD2
	SCHEMBL447665	0.80	HDAC8 (0.54)	HDAC8SMN1; SMN2ALDH1A1ADRA1AADRA1B
	SCHEMBL444884	0.79	HDAC8 (0.55)	HDAC8
	SCHEMBL443999	0.73	HDAC8 (0.52)	HDAC8SMN1; SMN2ALDH1A1NPC1
	SCHEMBL7413456	0.71	PDE4A (0.68)	HDAC8PDE4APDE4BPDE4CPDE4D
	SCHEMBL445526	0.70	CA12 (0.47)	HDAC8CA12CA1CA2CA7
	SCHEMBL650085	0.70	PDE4A (0.50)	HDAC8PDE4APDE4BPDE4CPDE4D
	SCHEMBL443398	0.70	HDAC8 (1.00)	HDAC8PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.