SCHEMBL447665

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL443233	0.88	HDAC8 (0.52)	HDAC8LMNAMEN1KMT2AALDH1A1
	SCHEMBL444884	0.87	HDAC8 (0.55)	HDAC8ERAP1LMNAHDAC6
	SCHEMBL443508	0.86	HDAC8 (0.52)	HDAC8HSD11B1HDAC6
	SCHEMBL444917	0.85	HDAC8 (0.52)	HDAC8ERAP1LMNAMEN1KMT2A
	SCHEMBL444812	0.81	HDAC8 (0.61)	HDAC8CA1CA2HTTHDAC6
	SCHEMBL443678	0.80	HDAC8 (0.54)	HDAC8GAACA1CA2SMN1; SMN2
	SCHEMBL444289	0.70	MEN1 (0.50)	HDAC8MEN1KMT2ASMN1; SMN2DRD2
	SCHEMBL445402	0.70	HDAC8 (0.50)	HDAC8MEN1KMT2A
	SCHEMBL649320	0.70	FNTA (0.51)	HDAC8MEN1KMT2ASMN1; SMN2PKM
	SCHEMBL442939	0.70	HDAC8 (1.00)	HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.