Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611223 | 0.98 | TSHR (0.47) | TSHRTDP1ALDH1A1CYP3A4PDE7A | |
| SCHEMBL3612247 | 0.88 | TDP1 (0.54) | TSHRTDP1ALDH1A1CYP3A4CCR6 | |
| SCHEMBL629679 | 0.79 | TSHR (0.55) | TSHRTDP1ALDH1A1CYP3A4CCR6 | |
| SCHEMBL1330407 | 0.79 | TSHR (0.55) | TSHRTDP1ALDH1A1CYP3A4CCR6 | |
| SCHEMBL3864393 | 0.79 | TSHR (0.54) | TSHRTDP1ALDH1A1CYP3A4CCR6 | |
| SCHEMBL259813 | 0.79 | TSHR (0.60) | TSHRTDP1ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL10610184 | 0.79 | ALDH1A1 (0.47) | TSHRTDP1ALDH1A1CYP3A4PDE7A | |
| SCHEMBL8903476 | 0.79 | ALDH1A1 (0.55) | TSHRTDP1ALDH1A1CYP3A4PDE7A | |
| SCHEMBL18829958 | 0.79 | CYP1A2 (0.55) | TSHRTDP1ALDH1A1CYP3A4CCR6 | |
| SCHEMBL938651 | 0.77 | GPR35 (0.61) | TSHRTDP1ALDH1A1CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057168-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |