SCHEMBL4437211

SCHEMBL4437211

Cc1onc(O)c1C(C)C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 2/20 0.36
GRIA3 P42263 2/20 0.36
GAA P10253 2/20 0.33
GRIA2 P42262 1/20 0.32
GRIA4 P48058 1/20 0.32
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aspartic Acid SCHEMBL5964784 0.85 GRIA1 (0.43) GRIA1GRIA3GRIA2GRIA4MEN1
SCHEMBL29262695 0.79 GRIA1 (0.49) GRIA1GRIA3GAAGRIA2GRIA4
SCHEMBL13319909 0.79 GRIA1 (0.41) GRIA1GRIA3GAAGRIA2GRIA4
SCHEMBL5290687 0.79 GRIA1 (0.41) GRIA1GRIA3GAAGRIA2GRIA4
SCHEMBL6809086 0.79 CACNA1F (0.33)
SCHEMBL8609634 0.75 GRIA1 (0.40) GRIA1GRIA3GAAGRIA2GRIA4
SCHEMBL68800 0.75
SCHEMBL2575298 0.75
Bromide SCHEMBL7200266 0.74
SCHEMBL5062987 0.72 GRIA1 (0.39) GRIA1GRIA3GAAGRIA2GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2066323-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING COMBINATIONS OF AN AMPA/KAINATE ANTAGONISTIC COMPOUND AND AN INHIBITOR OF A MULTIDRUG RESISTANCE PROTEIN NeuroSearch AS (DK) 2009-06-10 EP claimed
WO-2008031831-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING COMBINATIONS OF AN AMPA/KAINATE ANTAGONISTIC COMPOUND AND AN INHIBITOR OF A MULTIDRUG RESISTANCE PROTEIN NEUROSEARCH A/S (DK) 2008-03-20 WO claimed
US-7192931-B2 Treatment of demyelinating diseases NEUREN PHARMACEUTICALS LTD. (NZ) 2007-03-20 US claimed
WO-2025030033-A1 APILIMOD COMPOSITIONS AND METHODS OF USE ORPHAI THERAPEUTICS INC. (US) 2025-02-06 WO disclosed
EP-4188382-A1 ADMINISTRATION OF MODULATORS OF 5-HT AND/OR AMPA RECEPTORS FOR TREATING NEUROLOGICAL CONDITIONS The Royal Institution for the Advancement of Learning / McGill University (CA) 2023-06-07 EP disclosed
WO-2022023813-A1 ADMINISTRATION OF MODULATORS OF 5-HT AND/OR AMPA RECEPTORS FOR TREATING NEUROLOGICAL CONDITIONS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2022-02-03 WO disclosed
CN-113425690-A Perampanel orally disintegrating tablet and preparation method thereof 北京万全德众医药生物技术有限公司 2021-09-24 CN disclosed
CN-106389367-B Perampanel coated tablet pharmaceutical composition 杭州朱养心药业有限公司 2020-12-18 CN disclosed
CN-107616969-B Rapidly disintegrating pharmaceutical composition of Perampanel tablets 杭州朱养心药业有限公司 2020-09-18 CN disclosed
US-20180318279-A1 TOPICAL COMPOSITIONS PROVIDING PAIN RELIEF AND METHODS OF USE THEREOF RUSH UNIVERSITY MEDICAL CENTER (US) 2018-11-08 US disclosed
US-20170312308-A1 XENON AND/OR ARGON TREATMENT AS AN ADJUNCT TO PSYCHOTHERAPY FOR PSYCHIATRIC DISORDERS THE MCLEAN HOSPITAL CORPORATION (US) 2017-11-02 US disclosed
WO-1998027097-A1 TRICYCLIC QUINOXALINE DERIVATIVES AS NEUROPROTECTIVE AGENTS WARNER-LAMBERT COMPANY (US) 1998-06-25 WO disclosed
EP-0837854-A1 ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-04-29 EP disclosed
EP-0832074-A1 AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-04-01 EP disclosed
WO-1996040649-A1 AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1996-12-19 WO disclosed
WO-1996040651-A1 ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1996-12-19 WO disclosed
WO-1995007887-A1 INDOLE DERIVATIVES AS ANTAGONISTS OF EXCITATORY AMINO ACIDS GLAXO S.P.A. (IT) 1995-03-23 WO disclosed
EP-0486621-A4 NMDA OXIDIZING AGENTS FOR PROTECTING NEURONS FROM INJURY 1993-03-31 EP disclosed
EP-0486621-A1 NMDA OXIDIZING AGENTS FOR PROTECTING NEURONS FROM INJURY The Children's Medical Center Corporation (US) 1992-05-27 EP disclosed
WO-1991002810-A1 NMDA OXIDIZING AGENTS FOR PROTECTING NEURONS FROM INJURY THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 1991-03-07 WO disclosed