Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604296 | 0.88 | MEN1 (0.45) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8599115 | 0.87 | MEN1 (0.45) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8603489 | 0.86 | ABCB1 (0.46) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL3237705 | 0.85 | HTR4 (0.56) | HTR4MEN1ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL27144286 | 0.84 | ACHE (0.62) | HTR4ACHE | |
| SCHEMBL7259062 | 0.82 | HTR4 (0.40) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL3230374 | 0.82 | HTR4 (0.61) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8971273 | 0.78 | HTR4 (0.61) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8600089 | 0.78 | MEN1 (0.45) | HTR4MEN1ALDH1A1CYP2D6KMT2A | |
| SCHEMBL8602267 | 0.75 | MEN1 (0.62) | HTR4MEN1ALDH1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076288-A2 | COMBINATION COMPRISING AN HMG-COA REDUCTASE INHIBITOR AND A SECOND NEUROGENIC AGENT FOR TREATING A NERVOUS SYSTEM DISORDER AND INCREASING NEUROGENESIS | Braincells, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1942879-A1 | GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS | Braincells, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1937236-A2 | MODULATION OF NEUROGENESIS BY HDAC INHIBITION | Braincells, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2008036846-A2 | COMBINATION COMPRISING AN HMG-COA REDUCTASE INHIBITOR AND A SECOND NEUROGENIC AGENT FOR TREATING A NERVOUS SYSTEM DISORDER AND INCREASING NEUROGENESIS | BRAINCELLS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007053596-A1 | GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS | BRAINCELLS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007030697-A2 | MODULATION OF NEUROGENESIS BY HDAC INHIBITION | BRAINCELLS, INC. (US) | 2007-03-15 | — | — | WO | disclosed |