Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259161 | 0.87 | KCNH2 (0.34) | DRD2 | |
| SCHEMBL4437515 | 0.82 | HTR4 (0.54) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL7254150 | 0.82 | HTR4 (0.45) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| Hydrochloric Acid SCHEMBL7254030 | 0.81 | SLC6A2 (0.40) | — | |
| SCHEMBL8604296 | 0.75 | MEN1 (0.45) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| Hydrochloric Acid SCHEMBL8599115 | 0.75 | MEN1 (0.45) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL7254146 | 0.73 | HTR4 (0.48) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL7401197 | 0.71 | HTR4 (0.62) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL6328102 | 0.71 | HTR4 (0.70) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL6333842 | 0.70 | HTR4 (0.58) | HTR4ACHECYP2D6CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |