SCHEMBL4437860

SCHEMBL4437860

NOB(O)c1cccc(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.41
IDO1 P14902 2/20 0.41
AGXT P21549 2/20 0.41
ALDH1A1 P00352 2/20 0.40
TSHR P16473 1/20 0.40
WDR5 P61964 1/20 0.40
PARP1 P09874 1/20 0.38
HTR3E A5X5Y0 3/20 0.37
HTR3B O95264 3/20 0.37
HTR3A P46098 3/20 0.37
HTR3D Q70Z44 3/20 0.37
HTR3C Q8WXA8 3/20 0.37
SLC22A2 O15244 1/20 0.37
SLC22A1 O15245 1/20 0.37
SLC22A3 O75751 1/20 0.37
PLAU P00749 1/20 0.37
ENPP2 Q13822 2/20 0.36
PNMT P11086 1/20 0.36
ORAI1 Q96D31 1/20 0.36
ORAI2 Q96SN7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7461964 0.80 TSHR (0.40) CYP3A4IDO1AGXTALDH1A1TSHR
SCHEMBL19820142 0.80 ENPP2 (0.41) ALDH1A1TSHRWDR5PARP1ENPP2
SCHEMBL28043672 0.80 TSHR (0.40) CYP3A4IDO1AGXTALDH1A1TSHR
SCHEMBL17725984 0.79 CYP3A4 (0.44) CYP3A4IDO1AGXTALDH1A1TSHR
SCHEMBL31492054 0.77 TSHR (0.38) CYP3A4IDO1AGXTALDH1A1TSHR
SCHEMBL1138514 0.76 ORAI1 (0.54) ALDH1A1TSHRWDR5PARP1HTR3E
SCHEMBL11815 0.76 ENPP2 (0.56) ALDH1A1TSHRENPP2ORAI1ORAI2
SCHEMBL26345899 0.76 ACHE (0.42) IDO1ALDH1A1PARP1HTR3EHTR3B
SCHEMBL28799132 0.76 IDO1 (0.41) CYP3A4IDO1AGXTALDH1A1PARP1
SCHEMBL4832666 0.74 CYP2D6 (0.36) CYP3A4IDO1AGXTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2018146-A2 COMPOSITIONS FOR OXIDATIVELY DYEING KERATIN FIBERS AND METHODS FOR USING SUCH COMPOSITIONS The Procter and Gamble Company (US) 2009-01-28 EP disclosed
WO-2007102126-A2 COMPOSITIONS FOR OXIDATIVELY DYEING KERATIN FIBERS AND METHODS FOR USING SUCH COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2007-09-13 WO disclosed