Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 15/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 15/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PER2 | O15055 | 1/20 | 0.39 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.39 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427287 | 0.92 | KEAP1 (0.43) | KEAP1NFE2L2TP53PER2CRY1 | |
| SCHEMBL4433156 | 0.92 | KEAP1 (0.52) | KEAP1NFE2L2TP53PPARGPER2 | |
| SCHEMBL4432775 | 0.88 | TP53 (0.41) | KEAP1NFE2L2TP53PER2CRY1 | |
| SCHEMBL13390109 | 0.87 | PER2 (0.36) | KEAP1NFE2L2PER2CRY1CRY2 | |
| SCHEMBL10317516 | 0.85 | KEAP1 (0.48) | KEAP1NFE2L2TP53PPARGPER2 | |
| SCHEMBL2850695 | 0.81 | TP53 (0.44) | KEAP1NFE2L2TP53PER2CRY1 | |
| SCHEMBL13389979 | 0.80 | PER2 (0.38) | KEAP1NFE2L2TP53PER2CRY1 | |
| SCHEMBL10356579 | 0.79 | PER2 (0.39) | KEAP1NFE2L2PER2CRY1CRY2 | |
| SCHEMBL3305106 | 0.78 | PTGS2 (0.34) | PER2CRY1CRY2 | |
| SCHEMBL13389986 | 0.77 | PER2 (0.35) | KEAP1NFE2L2TP53PER2CRY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |
| EP-2121600-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099000-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |