Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TACR3 | P29371 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049768 | 0.89 | LMNA (0.63) | LMNAL3MBTL1TACR3TP53GAA | |
| SCHEMBL16553849 | 0.84 | LMNA (0.67) | LMNAL3MBTL1TACR3TP53CYP2C19 | |
| SCHEMBL3870523 | 0.82 | LMNA (0.65) | LMNAL3MBTL1TACR3TP53CYP2D6 | |
| Hydrochloric Acid SCHEMBL5499021 | 0.81 | LMNA (0.64) | LMNAL3MBTL1TACR3TP53CYP2D6 | |
| SCHEMBL4667125 | 0.80 | LMNA (0.62) | LMNAL3MBTL1TACR3TP53CNR1 | |
| SCHEMBL5139952 | 0.80 | LMNA (0.61) | LMNAL3MBTL1TACR3TP53GAA | |
| SCHEMBL1581075 | 0.79 | CYP2D6 (0.72) | LMNATACR3GAACYP2D6CYP2C19 | |
| SCHEMBL5046700 | 0.79 | LMNA (0.61) | LMNAL3MBTL1TACR3TP53CNR1 | |
| SCHEMBL5049830 | 0.79 | LMNA (0.67) | LMNAL3MBTL1TACR3TP53CNR1 | |
| SCHEMBL5047970 | 0.79 | LMNA (0.67) | LMNAL3MBTL1TACR3TP53CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137155-A1 | QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | AstraZeneca AB (SE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115140-A1 | QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | WO | disclosed |