Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL1929898 | 0.94 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| SCHEMBL381410 | 0.89 | ALDH1A1 (0.64) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL28859780 | 0.89 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL10736240 | 0.89 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL28358071 | 0.88 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL8209798 | 0.88 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL123278 | 0.88 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL1366420 | 0.88 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL8210119 | 0.85 | TSHR (0.75) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL5706612 | 0.85 | TSHR (0.75) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4294859-B2 | — | — | 2009-07-15 | — | — | JP | claimed |
| EP-1044232-B1 | RECLAIMED POLY(ETHYLENE TEREPHTHALATE) COATING | SUN CHEMICAL CORP (US) | 2004-08-04 | — | — | EP | claimed |
| JP-2002514661-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-1023369-B1 | DEPOLYMERIZATION PROCESS FOR RECYCLING POLYESTERS | EASTMAN CHEM CO (US) | 2002-01-16 | — | — | EP | claimed |
| US-6136869-A | USING ALCOHOL SUCH AS METHANOL, ETHANOL AND, OR PROPANOL | EASTMAN CHEMICAL COMPANY (US) | 2000-10-24 | — | — | US | claimed |
| EP-1044232-A1 | RECLAIMED POLY(ETHYLENE TEREPHTHALATE) COATING | SUN CHEMICAL CORPORATION (US) | 2000-10-18 | — | — | EP | claimed |
| US-6127436-A | REACTING POLYETHYLENE TEREPHTHALATE PARTICLES WITH GLYCOL AND POLYHYDRIC ALIPHATIC ALCOHOL IN THE PRESENCE OF ALCOHOLYSIS CATALYST TO CONVERT POLYMER INTO OLIGOMERIC POLYOL, CONTACTING OLIGOMER WITH ACID UNDER ESTERIFICATION CONDITIONS | SUN CHEMICAL CORPORATION (US) | 2000-10-03 | — | — | US | claimed |
| EP-1023369-A1 | DEPOLYMERIZATION PROCESS FOR RECYCLING POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 2000-08-02 | — | — | EP | claimed |
| WO-2000024802-A1 | RECLAIMED POLY(ETHYLENE TEREPHTHALATE) COATING | SUN CHEMICAL CORPORATION (US) | 2000-05-04 | — | — | WO | claimed |
| WO-1999020684-A1 | DEPOLYMERIZATION PROCESS FOR RECYCLING POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 1999-04-29 | — | — | WO | claimed |
| EP-1044232-B1 | RECLAIMED POLY(ETHYLENE TEREPHTHALATE) COATING | SUN CHEMICAL CORP (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-1044232-A1 | RECLAIMED POLY(ETHYLENE TEREPHTHALATE) COATING | SUN CHEMICAL CORPORATION (US) | 2000-10-18 | — | — | EP | disclosed |
| US-6127436-A | REACTING POLYETHYLENE TEREPHTHALATE PARTICLES WITH GLYCOL AND POLYHYDRIC ALIPHATIC ALCOHOL IN THE PRESENCE OF ALCOHOLYSIS CATALYST TO CONVERT POLYMER INTO OLIGOMERIC POLYOL, CONTACTING OLIGOMER WITH ACID UNDER ESTERIFICATION CONDITIONS | SUN CHEMICAL CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| WO-2000024802-A1 | RECLAIMED POLY(ETHYLENE TEREPHTHALATE) COATING | SUN CHEMICAL CORPORATION (US) | 2000-05-04 | — | — | WO | disclosed |