Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438837 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAAGLAPDE3B | |
| SCHEMBL4426842 | 0.89 | KDM4E (0.49) | ALDH1A1KDM4EGAAGLANR4A2 | |
| SCHEMBL5154097 | 0.88 | KDM4E (0.54) | ALDH1A1KDM4EGAAGLAMMP2 | |
| SCHEMBL4430692 | 0.86 | KDM4E (0.51) | KDM4EMMP1MMP2MMP12ACLY | |
| SCHEMBL4430805 | 0.84 | KDM4E (0.47) | ALDH1A1KDM4EGAAGLAMMP1 | |
| SCHEMBL4428809 | 0.84 | DAO (0.48) | ALDH1A1KDM4EGAAGLAMMP1 | |
| SCHEMBL4437957 | 0.84 | PDE3B (0.51) | ALDH1A1KDM4EGAAGLAMMP1 | |
| SCHEMBL4428291 | 0.82 | KDM4E (0.48) | ALDH1A1KDM4EGAAGLAPDE10A | |
| SCHEMBL4426834 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EGAAGLAPDE3B | |
| SCHEMBL4429436 | 0.79 | KDM4E (0.53) | ALDH1A1KDM4EGAAGLAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |