Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.42 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432424 | 0.89 | HNF4A (0.49) | KDM4EACMSDHNF4APTPN1KDM4A | |
| SCHEMBL4433258 | 0.87 | KDM4E (0.55) | KDM4EACMSDGPR84HNF4APTPN1 | |
| SCHEMBL3912930 | 0.87 | KDM4E (0.53) | KDM4EHNF4APTPN1KDM4AKDM5B | |
| SCHEMBL4438532 | 0.86 | ALDH1A1 (0.47) | KDM4EACMSDHRH3GPR84MMP1 | |
| SCHEMBL4428237 | 0.84 | KDM4E (0.50) | KDM4EHNF4APTPN1KDM4AKDM5B | |
| SCHEMBL4438623 | 0.83 | HCAR2 (0.54) | KDM4EMMP1MMP2MMP12DCLRE1B | |
| SCHEMBL4380912 | 0.83 | HCAR2 (0.54) | KDM4EMMP1MMP2MMP12KDM4A | |
| SCHEMBL4431491 | 0.83 | HCAR2 (0.54) | KDM4EMMP1MMP2MMP12KDM4A | |
| SCHEMBL4438787 | 0.83 | KDM4E (0.41) | KDM4EACMSDHNF4AKDM4AKDM5B | |
| SCHEMBL4431596 | 0.82 | KDM4E (0.45) | KDM4EHNF4ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |