Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447866 | 0.86 | CYP3A4 (0.42) | CYP3A4CA1CA2TSHRNR1H4 | |
| SCHEMBL19461805 | 0.77 | GAA (0.48) | TSHRHSD17B10ALDH1A1HPGDCASP1 | |
| SCHEMBL3781096 | 0.77 | CYP3A4 (0.52) | CYP3A4CA1CA2TSHRNR1H4 | |
| SCHEMBL8128654 | 0.77 | CYP3A4 (0.52) | CYP3A4CA1CA2TSHRNR1H4 | |
| SCHEMBL2817983 | 0.76 | KMT2A (0.56) | NR1H4HSD17B10ALDH1A1MAPTKMT2A | |
| SCHEMBL19815146 | 0.76 | MAPT (0.53) | ALDH1A1MAPTKMT2A | |
| SCHEMBL27776101 | 0.75 | CYP3A4 (0.50) | CYP3A4CA1CA2TSHRNR1H4 | |
| SCHEMBL10781060 | 0.71 | CYP3A4 (0.42) | CYP3A4CA1CA2TSHRNR1H4 | |
| SCHEMBL2817651 | 0.71 | NR1H4 (0.44) | CYP3A4CA1CA2TSHRNR1H4 | |
| SCHEMBL4573292 | 0.70 | ADRB1 (0.54) | CYP3A4TSHRHSD17B10ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134676-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Addex Pharma SA (CH) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008117175-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | ADDEX PHARMA SA (CH) | 2008-10-02 | — | — | WO | disclosed |