Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438662 | 1.00 | ATM (0.37) | ATMTDP1SMN1; SMN2MEN1LMNA | |
| SCHEMBL2532268 | 0.85 | ALDH1A1 (0.49) | ATMTDP1SMN1; SMN2MEN1LMNA | |
| SCHEMBL29434843 | 0.82 | L3MBTL1 (0.40) | TDP1SMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL2530387 | 0.82 | L3MBTL1 (0.40) | TDP1SMN1; SMN2MEN1LMNAMAPT | |
| SCHEMBL2532560 | 0.81 | ALDH1A1 (0.35) | ATMTDP1SMN1; SMN2LMNAMAPT | |
| SCHEMBL21806057 | 0.79 | HPGD (0.34) | TDP1SMN1; SMN2MEN1MAPTHTT | |
| SCHEMBL30365148 | 0.79 | HPGD (0.34) | TDP1SMN1; SMN2MEN1MAPTHTT | |
| SCHEMBL3393064 | 0.77 | L3MBTL1 (0.43) | TDP1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL7752147 | 0.74 | MAPT (0.37) | ATMTDP1MAPTHTTALDH1A1 | |
| SCHEMBL2533200 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2LMNAMAPTALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129657-A2 | PROCESS FOR PREPARING INDOL-5-OXY-QUINAZOLINE DERIVATIVES AND INTERMEDIATES | AstraZeneca AB (SE) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008053221-A2 | PROCESS FOR PREPARING INDOL- 5 -OXY- QUINAZOLINE DERIVATIVES AND INTERMEDIATES | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |