Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408705 | 0.91 | LMNA (0.40) | LMNATAAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL3405865 | 0.91 | LMNA (0.40) | LMNATAAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL1564436 | 0.86 | LMNA (0.48) | LMNATAAR1TSHRCYP2C19BCHE | |
| SCHEMBL17824072 | 0.86 | LMNA (0.48) | LMNATAAR1TSHRCYP2C19BCHE | |
| SCHEMBL2347159 | 0.86 | LMNA (0.48) | LMNATAAR1TSHRCYP2C19BCHE | |
| SCHEMBL1193827 | 0.81 | FASN (0.42) | TAAR1CYP3A4 | |
| SCHEMBL9660776 | 0.80 | TSHR (0.44) | LMNATSHRPDE4DMEN1KMT2A | |
| SCHEMBL10582642 | 0.80 | TSHR (0.44) | LMNATSHRPDE4DMEN1KMT2A | |
| SCHEMBL25251528 | 0.80 | ALDH1A1 (0.42) | LMNAMEN1KMT2AALDH1A1MGLL | |
| SCHEMBL21565332 | 0.79 | CTSD (0.40) | LMNATSHRALDH1A1CYP2C19BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125829-A2 | BICYCLIC OXOMORPHOLINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008108378-A2 | BICYCLIC OXOMORPHOLINE DERIVATIVE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-12 | — | — | WO | disclosed |