Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241640 | 0.77 | HSD11B1 (0.44) | HSD11B1MCHR1PARP15PARP10PARP2 | |
| SCHEMBL242444 | 0.76 | POLB (0.42) | HSD11B1MCHR1 | |
| SCHEMBL240258 | 0.75 | HSD11B1 (0.45) | HSD11B1MCHR1 | |
| SCHEMBL942960 | 0.73 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL238436 | 0.70 | GPR119 (0.44) | HSD11B1MCHR1 | |
| SCHEMBL242303 | 0.70 | HSD11B1 (0.42) | HSD11B1MCHR1 | |
| SCHEMBL943859 | 0.70 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL944330 | 0.69 | GPR119 (0.45) | HSD11B1MCHR1 | |
| SCHEMBL1168079 | 0.68 | HSD11B1 (0.45) | HSD11B1PARP15PARP10 | |
| SCHEMBL943500 | 0.68 | HSD11B1 (0.44) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010479-A1 | 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115935-A1 | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2007-10-18 | — | — | WO | claimed |
| EP-2010479-A1 | 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115935-A1 | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2007-10-18 | — | — | WO | disclosed |