SCHEMBL1168079

SCHEMBL1168079

CN(C(=O)c1cccc(OCC2CCCCC2)c1)C1C2CC3CC1CC(O)(C3)C2

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.45
ADAM17 P78536 1/20 0.42
SLC2A1 P11166 1/20 0.42
KAT6A Q92794 1/20 0.41
NR1H4 Q96RI1 1/20 0.39
SIRT2 Q8IXJ6 1/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
PARP15 Q460N3 2/20 0.38
PARP10 Q53GL7 2/20 0.38
FAAH O00519 1/20 0.38
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1169240 0.82 MEN1 (0.51) HSD11B1RAB9ASMN1; SMN2FAAHCNR2
SCHEMBL3634002 0.82 THRB (0.51) HSD11B1NR1H4FAAH
SCHEMBL1168251 0.81 HSD11B1 (0.45) HSD11B1ADAM17SLC2A1NR1H4FAAH
SCHEMBL16280954 0.80 SLC2A1 (0.42) ADAM17SLC2A1KAT6ANR1H4SIRT2
SCHEMBL1168472 0.78 HSD11B1 (0.49) HSD11B1FAAHCNR2
SCHEMBL1169157 0.78 HSD11B1 (0.48) HSD11B1SMN1; SMN2FAAHCNR2
SCHEMBL1168346 0.78 POLB (0.42) HSD11B1RAB9A
SCHEMBL16281052 0.77 SLC2A1 (0.42) ADAM17SLC2A1KAT6ANR1H4SIRT2
SCHEMBL19381466 0.76 ADAM17 (0.40) ADAM17SLC2A1KAT6ANR1H4SIRT2
SCHEMBL241640 0.76 HSD11B1 (0.44) HSD11B1PARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110039853-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC 2011-02-17 US claimed
EP-2150526-A2 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE High Point Pharmaceuticals, LLC (US) 2010-02-10 EP claimed
WO-2008101914-A2 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC (GB) 2008-08-28 WO claimed
EP-2150526-B1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE VTV THERAPEUTICS LLC (US) 2017-09-20 EP disclosed
EP-2150526-B1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE VTV THERAPEUTICS LLC (US) 2017-09-20 EP disclosed
US-8907096-B2 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase HIGH POINT PHARMACEUTICALS, LLC (US) 2014-12-09 US disclosed
US-20140315905-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE VTV THERAPEUTICS LLC 2014-10-23 US disclosed
US-20140315905-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE VTV THERAPEUTICS LLC 2014-10-23 US disclosed
US-20140315905-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE VTV THERAPEUTICS LLC 2014-10-23 US disclosed
US-8809540-B2 N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase HIGH POINT PHARMACEUTICALS, LLC (US) 2014-08-19 US disclosed
US-8809540-B2 N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase HIGH POINT PHARMACEUTICALS, LLC (US) 2014-08-19 US disclosed
US-20130231341-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC (US) 2013-09-05 US disclosed
US-8383820-B2 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase HIGH POINT PHARMACEUTICALS, LLC (US) 2013-02-26 US disclosed
US-8383820-B2 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase HIGH POINT PHARMACEUTICALS, LLC (US) 2013-02-26 US disclosed
US-8383820-B2 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase HIGH POINT PHARMACEUTICALS, LLC (US) 2013-02-26 US disclosed
US-20110039853-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC 2011-02-17 US disclosed
US-20110039853-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC 2011-02-17 US disclosed
US-20110039853-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC 2011-02-17 US disclosed
EP-2150526-A2 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE High Point Pharmaceuticals, LLC (US) 2010-02-10 EP disclosed
WO-2008101914-A2 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HIGH POINT PHARMACEUTICALS, LLC (GB) 2008-08-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110039853-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HSD11B1, HSD3B1, HSD17B1 HSD11B1 1/4885ADAM17 463/4885SLC2A1 2393/4885
US-20130231341-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HSD11B1, HSD3B1, HSD17B1 HSD11B1 1/4885ADAM17 463/4885SLC2A1 2393/4885
US-20140315905-A1 N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE HSD11B1, HSD3B1, HSD17B1 HSD11B1 1/4885ADAM17 463/4885SLC2A1 2393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.