Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445222 | 0.87 | RPLP1 (0.40) | EPHX2ALDH1A1MC4RMEN1KMT2A | |
| SCHEMBL4442462 | 0.86 | MEN1 (0.36) | SLC6A2SLC6A4MEN1KMT2ASLC6A3 | |
| SCHEMBL4444981 | 0.85 | SLC6A4 (0.40) | ALDH1A1SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL4437622 | 0.84 | GAA (0.35) | SLC6A2SLC6A4MEN1KMT2ASLC6A3 | |
| SCHEMBL4434907 | 0.84 | TACR1 (0.40) | ALDH1A1SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL4439400 | 0.83 | POLB (0.40) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5214565 | 0.82 | SLC6A2 (0.37) | SLC6A2SLC6A4MEN1KMT2ASLC6A3 | |
| SCHEMBL4434449 | 0.81 | MAPK1 (0.40) | ALDH1A1SMN1; SMN2SLC6A2SLC6A4MEN1 | |
| SCHEMBL573598 | 0.81 | QPCT (0.41) | HTR4ALDH1A1SLC6A2SLC6A4MEN1 | |
| SCHEMBL574274 | 0.80 | EHMT2 (0.39) | HTR4SLC6A2SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |