Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 5/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574202 | 0.84 | LMNA (0.36) | EHMT2MEN1KMT2A | |
| SCHEMBL573598 | 0.81 | QPCT (0.41) | EHMT2HTR4QPCTSLC6A4SLC6A2 | |
| SCHEMBL4439262 | 0.80 | EPHX2 (0.39) | HTR4SLC6A4SLC6A2TACR1MEN1 | |
| SCHEMBL4442462 | 0.80 | MEN1 (0.36) | SLC6A4SLC6A2TACR1MEN1KMT2A | |
| SCHEMBL4439470 | 0.80 | MEN1 (0.36) | SLC6A4SLC6A2TACR1MEN1KMT2A | |
| SCHEMBL5214565 | 0.78 | SLC6A2 (0.37) | SLC6A4SLC6A2MEN1KMT2ASLC6A3 | |
| SCHEMBL4444981 | 0.76 | SLC6A4 (0.40) | SLC6A4SLC6A2TACR1MEN1KMT2A | |
| SCHEMBL4437622 | 0.76 | GAA (0.35) | SLC6A4SLC6A2TACR1MEN1KMT2A | |
| SCHEMBL4434907 | 0.76 | TACR1 (0.40) | SLC6A4SLC6A2TACR1SLC6A3 | |
| SCHEMBL27808000 | 0.72 | TACR1 (0.40) | SLC6A4SLC6A2TACR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601186-A2 | 4-(1H-INDOL-3-YL)-PYRIMIDINES AS ALK INHIBITORS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |