Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433912 | 0.87 | FLT3 (0.35) | GAAMAPTMAPK1CREBBPPRKCI | |
| SCHEMBL4434449 | 0.87 | MAPK1 (0.40) | GAAMAPTMAPK1SLC6A4SLC6A2 | |
| SCHEMBL4442462 | 0.86 | MEN1 (0.36) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL4444981 | 0.85 | SLC6A4 (0.40) | GAASLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL4434907 | 0.84 | TACR1 (0.40) | SLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL4439262 | 0.84 | EPHX2 (0.39) | SLC6A4GPR119SLC6A2SLC6A3MEN1 | |
| SCHEMBL4437157 | 0.83 | HCAR3 (0.39) | GAAMAPTMAPK1GPR119MEN1 | |
| SCHEMBL5214565 | 0.82 | SLC6A2 (0.37) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL4439470 | 0.80 | MEN1 (0.36) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL7455407 | 0.78 | GPR119 (0.36) | SLC6A4GPR119SLC6A2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |