Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.34 |
| ▸ | TTK | P33981 | 5/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814831 | 1.00 | LMNA (0.34) | LMNAPOLBNR3C1TTKNR3C2 | |
| SCHEMBL4566100 | 0.91 | KMT2A (0.36) | LMNAPOLBARPGR | |
| SCHEMBL4555973 | 0.90 | MAPT (0.36) | F10 | |
| SCHEMBL4863672 | 0.90 | MAPT (0.36) | F10 | |
| SCHEMBL4611328 | 0.89 | F10 (0.36) | POLBF10 | |
| SCHEMBL4810475 | 0.86 | TTK (0.31) | TTK | |
| SCHEMBL4566784 | 0.85 | RARA (0.43) | LMNAPGR | |
| SCHEMBL4864199 | 0.84 | PDE4A (0.39) | F10ERN1ROCK2 | |
| SCHEMBL4811546 | 0.84 | NPC1 (0.39) | POLB | |
| SCHEMBL14625088 | 0.84 | NPC1 (0.39) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |