Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 6/20 | 0.35 |
| ▸ | RARB | P10826 | 6/20 | 0.35 |
| ▸ | RARG | P13631 | 6/20 | 0.35 |
| ▸ | F10 | P00742 | 4/20 | 0.35 |
| ▸ | F7 | P08709 | 4/20 | 0.35 |
| ▸ | F11 | P03951 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863672 | 1.00 | MAPT (0.36) | MAPTTDP1RARARARBRARG | |
| SCHEMBL4566100 | 0.93 | KMT2A (0.36) | MAPTTSHRKDM4E | |
| SCHEMBL4566784 | 0.93 | RARA (0.43) | TDP1RARARARBRARGRXRA | |
| SCHEMBL4611328 | 0.91 | F10 (0.36) | MAPTF10F7F11TSHR | |
| SCHEMBL4439335 | 0.90 | LMNA (0.34) | F10 | |
| SCHEMBL4814831 | 0.90 | LMNA (0.34) | F10 | |
| SCHEMBL4864199 | 0.86 | PDE4A (0.39) | RARARARBRARGF10F7 | |
| SCHEMBL4811546 | 0.86 | NPC1 (0.39) | TDP1KDM4E | |
| SCHEMBL14625088 | 0.86 | NPC1 (0.39) | TDP1KDM4E | |
| SCHEMBL4597471 | 0.86 | ACACB (0.39) | MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |