Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44655 | 0.88 | THRB (0.39) | THRBMAPTALDH1A1KDM4EPOLB | |
| SCHEMBL44515 | 0.86 | MAPT (0.39) | THRBMAPTALDH1A1POLBUSP2 | |
| SCHEMBL13844940 | 0.85 | MAPT (0.46) | THRBMAPTPOLBKMT2AMEN1 | |
| SCHEMBL44282 | 0.84 | PPARA (0.41) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL44625 | 0.83 | MAPT (0.44) | THRBMAPTALDH1A1KDM4EPOLB | |
| SCHEMBL16602631 | 0.83 | ALDH1A1 (0.37) | THRBMAPTALDH1A1USP2KMT2A | |
| SCHEMBL43981 | 0.83 | MAPT (0.37) | THRBMAPTALDH1A1POLBUSP2 | |
| SCHEMBL16592815 | 0.82 | MAPT (0.43) | THRBMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL44472 | 0.82 | HTT (0.40) | MAPTKMT2ATP53 | |
| SCHEMBL43982 | 0.82 | PDCD1 (0.41) | THRBMAPTALDH1A1USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |