Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 6/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441455 | 0.86 | SLC6A2 (0.46) | EPHX2LMNAKMT2AHRH3 | |
| SCHEMBL5544755 | 0.77 | USP30 (0.58) | SRD5A1SRD5A2EPHX2ALDH1A1KMT2A | |
| SCHEMBL240368 | 0.77 | USP30 (0.58) | SRD5A1SRD5A2EPHX2ALDH1A1KMT2A | |
| SCHEMBL5545000 | 0.77 | USP30 (0.58) | SRD5A1SRD5A2EPHX2ALDH1A1KMT2A | |
| SCHEMBL14558058 | 0.76 | NAMPT (0.56) | SRD5A1SRD5A2EPHX2CYP2C9CYP2J2 | |
| SCHEMBL14610952 | 0.76 | SRD5A1 (0.51) | SRD5A1SRD5A2EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4448676 | 0.74 | DRD2 (0.46) | ALDH1A1KMT2A | |
| SCHEMBL1580337 | 0.73 | GAA (0.60) | SRD5A1SRD5A2ALDH1A1LMNAKMT2A | |
| SCHEMBL22664149 | 0.73 | ALDH1A1 (0.55) | SRD5A1SRD5A2EPHX2ALDH1A1LMNA | |
| SCHEMBL17869370 | 0.73 | ALDH1A1 (0.55) | SRD5A1SRD5A2EPHX2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010479-A1 | 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115935-A1 | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2007-10-18 | — | — | WO | disclosed |