Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441455 | 0.85 | SLC6A2 (0.46) | GPR119SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL631819 | 0.79 | DRD2 (0.52) | DRD2DRD4CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL15538226 | 0.79 | DRD2 (0.45) | DRD2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL241130 | 0.78 | GPR119 (0.59) | GPR119ALDH1A1 | |
| SCHEMBL31330775 | 0.76 | GPR119 (0.54) | DRD2DRD4GPR119ALDH1A1 | |
| SCHEMBL927657 | 0.76 | PARP15 (0.66) | DRD2DRD4MEN1KMT2A | |
| SCHEMBL15537887 | 0.74 | SSTR5 (0.45) | DRD2DRD4ALDH1A1TP53 | |
| SCHEMBL389145 | 0.74 | GPR119 (0.57) | GPR119 | |
| SCHEMBL15539028 | 0.74 | DRD2 (0.46) | DRD2DRD4TP53 | |
| SCHEMBL4440020 | 0.74 | SRD5A1 (0.49) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010479-A1 | 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115935-A1 | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2007-10-18 | — | — | WO | disclosed |