Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434033 | 1.00 | ALDH1A1 (0.48) | ALDH1A1CTDSP1SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL4432373 | 0.92 | KDM4E (0.43) | ALDH1A1CTDSP1KDM4ETDP1CASR | |
| SCHEMBL4429519 | 0.92 | KDM4E (0.43) | ALDH1A1CTDSP1KDM4ETDP1CASR | |
| SCHEMBL4433176 | 0.88 | LMNA (0.41) | ALDH1A1CTDSP1KDM4ETDP1LMNA | |
| SCHEMBL4432984 | 0.88 | LMNA (0.41) | ALDH1A1CTDSP1KDM4ETDP1LMNA | |
| SCHEMBL4433698 | 0.88 | LMNA (0.41) | ALDH1A1CTDSP1KDM4ETDP1LMNA | |
| SCHEMBL4431381 | 0.88 | ALDH1A1 (0.50) | ALDH1A1CTDSP1SMN1; SMN2KDM4ECASR | |
| SCHEMBL4432987 | 0.88 | ALDH1A1 (0.50) | ALDH1A1CTDSP1SMN1; SMN2KDM4ECASR | |
| SCHEMBL4433516 | 0.87 | KMT2A (0.43) | ALDH1A1CTDSP1SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL4434528 | 0.87 | KMT2A (0.43) | ALDH1A1CTDSP1SMN1; SMN2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | claimed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | claimed |
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |