Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.53 |
| ▸ | ACE | P12821 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440292 | 0.85 | MME (0.56) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL4442572 | 0.84 | MME (0.74) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL3623644 | 0.77 | MME (0.68) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL13821843 | 0.73 | CTSL (0.49) | ALDH1A1NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL9724958 | 0.73 | MAPT (0.62) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL2967426 | 0.72 | MME (0.50) | MMEACEALDH1A1HPGDMAPK1 | |
| SCHEMBL1817242 | 0.72 | PNMT (0.53) | PNMTFOLH1 | |
| SCHEMBL1817614 | 0.72 | PNMT (0.53) | PNMTFOLH1 | |
| SCHEMBL7281509 | 0.71 | MME (0.71) | MMEACEALDH1A1HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL4619275 | 0.71 | PNMT (0.51) | PNMTFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132187-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008097459-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-08-14 | — | — | WO | disclosed |